Romanian Society of Pharmaceutical Sciences

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PHYTOCHEMICAL PROFILING, ANTIOXIDANT AND CARDIOPROTECTIVE PROPERTIES OF PINOT NOIR CULTIVAR POMACE EXTRACTS

ŞTEFANIA SILVIA BALEA 1, ALINA ELENA PÂRVU 2*, NASTASIA POP 1, FERNANDO ZAMORA MARÍN 3, ANDRA ANDREICUȚ 2, MARCEL PÂRVU 4

1.Department of Horticulture and Landscaping, Faculty of Horticulture, University of Agricultural Sciences and Veterinary Medicine, 3-5 Calea Mănăştur Street, Cluj-Napoca 400372, Romania
2.Department of Pathophysiology, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 4-6 Victor Babeş Street, Cluj-Napoca 400012, Romania
3.Department of Biochemistry and Biotechnology, Faculty of Oenology, Rovira i Virgili University, C/Marcel.li Domingo s/n Street, Tarragona 43007, Spain
4.Department of Biology, Faculty of Biology and Geology, “Babeș-Bolyai” University, 42 Republicii Street, Cluj-Napoca 400015, Romania

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Fresh and fermented pomace extracts from Vitis vinifera L. Pinot noir were investigated. Total phenolic index, condensed tannins, total anthocyanins, proanthocyanidins, flavan-3-ol monomers, stilbenes and DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenger ability were measured. The effect of seven days pre-treatment on the isoprenaline-induced infarct-like lesion in rats was assessed by monitoring ECG and serum aspartate and alanine transaminase and creatine kinase. Oxidative stress was assessed by measuring serum total oxidative status, total antioxidant response, oxidative stress index, malondialdehyde, total thiols and nitric oxide. The extracts had high phenolic content and antioxidant activity. Both extracts improved ECG changes, cardiac markers and oxidative stress. In conclusions, fresh and fermented Pinot noir pomace extracts were cardio-protective by reducing oxidative stress.