Romanian Society of Pharmaceutical Sciences
 

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PHYTOCHEMICAL ANALYSIS, ANTIMICROBIAL AND ANTIOXIDANT EFFECT OF SOME GEMMOTHERAPIC REMEDIES USED IN RESPIRATORY DISEASES

MIHAELA ORODAN1, DAN CRISTIAN VODNAR2, ANCA MARIA TOIU3, CARMEN ELENA POP3*, LAURIAN VLASE3, ISTUDOR VIORICA4, ANDREEA LETIȚIA ARSENE4

1.Arad County Clinical Emergency Hospital Arad, 2-4 Andreny Karoly, Arad, Romania
2.University of Agricultural Sciences and Veterinary Medicine, Faculty of Food Science and Technology, 3-5 Manastur Street, Cluj Napoca, Romania
3.”Iuliu Hatieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, 8 V. Babes Street, Cluj Napoca, Romania
4.”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, sector 2, Bucharest, Romania

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The major objective of this study was the investigation of the antioxidant and antimicrobial potential of some gemmotherapic remedies obtained from several plants: Betula pubescens (BP), Ribes nigrum (RN), Rosa canina (RC), Viburnum lantana (VL) and Carpinus betulus (CB) often combined in therapeutic protocols with propolis tincture (P) to reduce certain symptoms of respiratory diseases. The phytochemical composition was also determined, in order to establish a correlation between the chemical composition and the already mentioned beneficial effects obtained upon administration. The results revealed an important amount of polyphenolic compounds for the propolis tincture (P) and consequently a very good antioxidant and antibacterial activity. Regarding the glycerinic extracts, RC and BP were the richest in total polyphenols and flavonoids, while the VL extract was the poorest in all analysed compounds. RC extract was the only one containing all three analysed triterpenes, with lupeol identified in the highest concentration. The P exhibited the best antibacterial activity, against all tested bacterial strains.