Romanian Society of Pharmaceutical Sciences
 

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PHYSICOCHEMICAL INVESTIGATION OF LOW SOLUBLE BIOCOMPOUNDS ENTRAPPED IN LIPID CARRIERS

CRISTINA DINU-PÎRVU1,2, MARIANA FERDES1, ALINA BUŢU2, ALINA ORŢAN3*, MIHAELA VIOLETA GHICA4

1University Politehnica of Bucharest, Romania
2 National Institute of Research and Development for Biological Sciences, Bucharest, Romania
3 University of Agricultural Sciences and Veterinary Medicine, Faculty of Biotechnology, Bucharest
4 University of Medicine and Pharmacy „Carol Davila”, Faculty of Pharmacy, Bucharest, Romania

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Lipid carriers were prepared by thin film hydration technique using various types of lipids, cholesterol and incorporating the drug in different weight ratios. The size and physical stability for the designed lipid carriers as well as the influence of the lipidic material and the experimental conditions on the entrapment efficiency were closely followed. All results showed that incorporation of low soluble drugs in lipid carriers is high when the appropriate formulations are used. The experimental studies were focused upon investigating the variations in the lipidic carriers characteristics (entrapment efficiency, size and stability) depending on the formulation parameters (weight ratio of phospholipids, cholesterol and drug). It was therefore shown that, by modifying the formulation, lipidic carriers with entrapment efficiencies over 90% can be obtained. Considering their stability, the lipid carriers content in incorporated low soluble drug was stable for one month, when stored at 4-6ºC.