PHENOLIC COMPOUNDS OF SERRATULA CENTAUROIDES AND ANXIOLYTIC EFFECT
SERGEI MATVEEVICH NIKOLAEV 1,3, IRINA GENNADYEVNA NIKOLAEVA 1,2*, YANINA GENNADYEVNA RAZUVAEVA 1,2, IRINCHEI EDUARDOVICH MATKHANOV 1, LILIYA PURBUEVNA TSYBIKTAROVA 2, LARISA NIKOLAEVNA SHANTANOVA 1,2, GALINA GRIGORYEVNA NIKOLAEVA 1,2
1.Institute of General and Experimental Biology SB RAS (IGEB SB RAS), 6 Sakhynovoi Street, 670047, Ulan-Ude, Russia
2.Buryat State University (BSU), 24a Smolina Street, Ulan-Ude, Russia
3.Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education, 100 Yubilejnyj, Irkutsk, Russia
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The paper presents the results of the study of a dry extract of Serratula centauroides (Asteraceae) using a HPLC method and estimation of his anxiolytic activity. 17 phenolic substances and 15 respectively were identified in the herb in the roots. In the herb of the plant, there were revealed hyperoside and luteolin. The aerial part contains twice as much ecdysterone as the roots of S. centauroides. The experiments conducted on animals have shown that the S. centauroides dry extract at the doses comprised between 50 - 150 mg/kg bw has a marked anxiolytic effect. S. centauroides extract increases the number of entries into the open branches of elevated plus maze (EPM) and prolongs a residence time in the open arms of EPM and light compartment of the dark/light chamber. The use of S. centauroides increases the number of punished water intakes in the Vogel conflict test.
