PHARMACOLOGICAL SCREENING REGARDING THE INFLUENCE OF SOME NEWLY SYNTHESIZED β-PHENYLETHYLAMINES ON THE SYSTOLIC AND DIASTOLIC BLOOD PRESSURE IN RATS
EMIL STEFĂNESCU, SIMONA NEGREȘ*, CORNEL CHIRIȚĂ, CRISTINA ELENA ZBÂRCEA, RĂZVAN NEAGU
Pharmacology and Clinical Pharmacy Department, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila – Traian Vuia str. no. 6 – Bucharest
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A series of newly synthesized β-phenylethylamines by the National Institute for
Chemical-Pharmaceutical Research and Development – Bucharest, Romania were studied.
The effects of these compounds on the systolic and diastolic blood pressure in rats were
investigated. The method used for this purpose was non-invasive as the blood pressure was
measured in the tail veins. The experimental results suggest that compounds noted C1
(20mg/kg), C2 (50mg/kg), C3 (100mg/kg), A1 (100mg/kg), A2 (100mg/kg), A5
(100mg/kg), A7 (100mg/kg) have an affinity for the α1 and/or β1 adrenergic receptors.
Compounds A1 and A5 especially stood out showing an increase of the systolic blood
pressure by 17.43% and respectively16.86% compared to the control group. All tested
compounds as well as the reference substance increased the low diastolic blood pressure
resulted from administrating prazosin in a statistically significant manner compared to the
control group. A possible competition between the tested compounds and prazosin for the
α1 adrenergic receptors could explain these results. However they can also be explained by
a possible non-selectivity of the tested compounds resulting in the stimulation of the
myocardic β1 adrenergic receptors. Based on the obtained results we can conclude that the
newly synthesized compounds have an affinity for both types of adrenergic receptors due to
the β-phenylethylamine molecular structure.