Romanian Society of Pharmaceutical Sciences

« Back to Farmacia Journal 1/2018

PHARMACOLOGICAL AND DISORDER ASSOCIATED CARDIOVASCULAR CHANGES IN PATIENTS WITH PSYCHOSIS. A COMPARISON BETWEEN OLANZAPINE AND RISPERIDONE

LIANA DEHELEAN 1#*, MINODORA ANDOR 2#, ANA MARIA ROMOŞAN 3#, MINODORA MARINELA MANEA 4#, RADU ŞTEFAN ROMOŞAN 1, ION PAPAVĂ 1, ANA CRISTINA BREDICEAN 1, VALENTINA OANA BUDA 5, MIRELA CLEOPATRA TOMESCU 2

1.Psychiatry, Neurosciences Department, “Victor Babeş” University of Medicine and Pharmacy, 2 E. Murgu Square, Timişoara, Romania
2.Medical Semiology II, Internal Medicine I Department, “Victor Babeş” University of Medicine and Pharmacy, 2 E. Murgu Square, Timişoara, Romania
3.“Victor Babeş” University of Medicine and Pharmacy, 2 E. Murgu Square, Timişoara, Romania
4.Psychology, Medical Education Department, “Iuliu Haţieganu” University of Medicine and Pharmacy, 8. V. Babeş Street, Cluj-Napoca, Romania
5.Pharmacology and Clinical Pharmacology, 2nd Department, “Victor Babeş” University of Medicine and Pharmacy, 2 E. Murgu Square, Timişoara, Romania
*corresponding author: lianadeh@umft.ro
#These authors contributed equally to this work and thus share first authorship.

Download Full Article PDF

Patients receiving antipsychotic medication present a high risk of cardiovascular complications due either to medication or to the disorder itself. This study compares the cardiovascular risk factors and echocardiographic parameters in two samples of outpatients with psychosis treated for at least 2 months with long acting injectable olanzapine or risperidone. We assessed the socio-demographic data, the cardiovascular risk factors, and the echocardiographic parameters. Subjects receiving risperidone had significantly more frequent regional myocardial contractility abnormalities (χ² = 6.896, p = 0.009) and diastolic dysfunction of the left ventricle than those on olanzapine (χ² = 5.416, p = 0.02), and were more frequently hypertensive. Patients with associated mood stabilizers presented more abnormalities related to the contractile function of the left ventricle than those receiving only antipsychotic treatment (χ² = 4.138, p = 0.042). There were no differences between the two samples concerning tobacco use or the presence of the metabolic syndrome.