Romanian Society of Pharmaceutical Sciences

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PERSPECTIVES IN THE EXPERIMENTAL STUDY OF THE METABOLIC SYNDROME

STELIANA GHIBU1, IOANA ILIE2*, ADRIANA MUREȘAN3, CRISTINA MOGOȘAN1

“Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
1.Department of Pharmacology, Physiology and Physiopathology; Faculty of Pharmacy
2.Department of Endocrinology, Faculty of Medicine
3.Department of Physiology, Faculty of Medicine

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The metabolic syndrome (MetS) is characterized by alterations of the glucose and lipid metabolism with long-lasting effects on the individual’s health state. Research animal models resembling the human MetS symptomatology have been designed throughout time in order to better understand and treat it. Currently, both the genetic animal model and the diet animal model can be used. The research animal models provide the advantage of a homogenous study which is able to more easily underline and quantify the consequences of the variation of several parameters such as: diet, obesity, hypertension, insulin resistance etc. This review presents the main experimental animal models that can be used in the study of MetS.