Romanian Society of Pharmaceutical Sciences

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PENTOXIFYLLINE AND INFLAMMATION MARKERS IN PATIENTS WITH ACUTE CORONARY SYNDROME

DANIEL MIRON BRIE 1, CRISTIAN MORNOS 1,2, DIDUTA ALINA BRIE 3*, TUDOR LUCA CONSTANTIN 1,2, LUCIAN PETRESCU 1,2, MADALINA BORUGA 4

1Department of Interventional Cardiology, Cardiovascular Disease Institute Timișoara, 13A Gheorghe Adam Street, 300310, Timișoara, Romania
2Department of Cardiology, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
3Department of Cellular Biology, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
4Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania

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In 500 consecutive patients with acute coronary syndrome, we added pentoxifylline 400 mg TID to standard therapy (group B) vs. placebo (group A). Blood was harvested for inflammatory markers (hsCRP, IL-6, TNF alpha) after admission, named T0, and at 48 h and 15 days after the acute event, called T1 and T2. We find that at 48 h (T1) was an attenuation of rise in hsCRP and TNF alpha level in group B compared with group A. Patients who received pentoxifylline (group B) attenuated the increase of hsCRP from baseline (1.25 ± 1.2 mg/L) to 48 hours (5.3 ± 1.6 mg/L), but not in group A patients who received a placebo (baseline 1.35 ± 1.2 mg/L and 48 hours 8.9 ± 2.2 mg/L, p < 0.001). The results were the same regarding TNF alpha level (administration of pentoxifylline reduced level in group B at 48 hours (at admission 33.4 ± 14.2 pg/L and 23 ± 19.3 pg/L at 48 hours), but not in group A (p < 0.001). However, the IL-6 level was not modified by the administration of pentoxifylline (group A, T0- 7.3 ± 5.1 pg/L and T1 24.4 ± 8.6 pg/L; group B, T0- 7.2 ± 4.8 pg/L and T1- 24.4 ± 8.6 pg/L, p = NS). At 15 days (T2) administration of pentoxifylline in group B normalized earlier the hsCRP and TNF alpha levels compared with group A (hsCRP - group A, T2- 4.4 ± 2.5 mg/L vs. group B, T2- 1.2 ± 1 mg/L, p < 0.001; TNF alpha- group A, T2-10.2 ± 7.3 pg/L vs. group B, T2-6.2 ± 3.4 pg/L, p < 0.001). This do not apply to IL-6 level at T2 (IL-6- group A, T2-12.5 ± 6.5 pg/L vs. group B, T2-11.3 ± 7.2 pg/L, p = NS). No correlation was found between the reduced level of inflammatory marker (hsCRP and TNF alpha) by adding pentoxifylline 400 mg TID to standard therapy.