Romanian Society of Pharmaceutical Sciences
 

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OXIDATIVE STRESS IN ALZHEIMER’S DEMENTIA

ANDRADA IOVA1, OTILIA MICLE1*, LAURA VICAȘ2, LIANA MICLE1, SORIN IOVA1, MARIANA MUREȘAN1, CORINA ANA IONIȚĂ3

1.University of Oradea, Medicine and Pharmacy Faculty, Department of Preclinical Disciplines, Oradea, Romania
2.University of Oradea, Department of Pharmacy, Oradea, Romania
3.University of Medicine and Pharmacy ”Carol Davila”, Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, 6 Traian Vuia Str., Bucharest, Romania

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The aim of this study was to evaluate oxidative stress on a group of patients with Alzheimer’s dementia (AD) and compare its parameters with a control group composed of mentally healthy subjects. This research involves patients diagnosed with AD from the Clinical Hospital for Neurology and Psychiatry of Oradea and from nursing homes for the elderly, whose levels of malondialdehyde (MDA), carbonylated proteins (CP) and ceruloplasmin (CER) have been determined. The results have been compared with those of a control group consisting of 40 persons of comparable age and educational levels and who had visited their general practitioner (GP) for regular checkups. Patients exhibited high levels of oxidative stress reflected by their elevated levels of malondialdehyde (MDA), carbonylated proteins (CP) and ceruloplasmin (CER).