Romanian Society of Pharmaceutical Sciences

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NEW MOLECULES IN MIGRAINE TREATMENT

ADINA ROCEANU1, FLORINA ANTOCHI1*, OVIDIU BAJENARU1,2

1.University Emergency Hospital Bucharest, Neurology Department
2.“Carol Davila” University of Medicine and Pharmacy Bucharest, Romania

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In the 1990s, serotonin receptor agonist 5-HT1B/1D (the triptans) became available on the market for migraine treatment. Although the triptans are highly effective in aborting migraine attacks, the vasoconstrictor effect in cerebral and coronary territory limits their use. In the “post-triptans” era, new molecules, without vasoactive components are about to expand migraine treatment armamentarium, such as: serotonin 5-HT1F receptor agonists, calcitonin gene related peptide (CGRP) receptor antagonists (olcegepant, telcagepant) and monoclonal antibodies (mAbs) targeting the CGRP, glutamate receptor (AMPA/kainate) antagonists, transient receptor potential vanilloid (TRV1) antagonists, nitric oxide (NO) synthesis inhibitors, prostanoid E4 receptor antagonists.