Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 6/2013

NEW MODIFIED RELEASE TABLETS WITH PENTOXIFYLLINE BASED ON LIPOPHILIC MATRIX. NOTE 2. STABILITY STUDY OF THE ACTIVE SUBSTANCE FROM THE PROPOSED FORMULATIONS

ELEONORA MIRCIA1*, SILVIA IMRE2, EMESE SIPOS3, VERONICA AVRIGEANU1, GABRIEL HANCU4, BARNA IANTOVICS5, TEODORA BALACI6

University of Medicine and Pharmacy Târgu-Mureş, Faculty of Pharmacy, Gh. Marinescu 38, 540139, Târgu-Mureş, Romania
1Organic Chemistry Department
2Drug Analysis Department
3Pharmaceutical Technology Department
4Pharmaceutical Chemistry Department
5“Petru Maior” University, Faculty of Science and Letters, Department of Mathematics and Informatics, Târgu-Mureş, Romania
6University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Pharmaceutical Technology Department, Bucharest, Romania

Download Full Article PDF

The objective of this study was to test the stability of pentoxifylline in experimental formulations based on lipophilic matrix. In order to achieve this, we studied the influence of heat stress on the stability of the proposed formulations, by keeping the product samples at high temperatures and humidity, in a stability chamber, during periods lasting from one to six months, sampling at different periods of time and then analyzing the test samples. Experimental results show that all the proposed formulations can be considered stable.