Romanian Society of Pharmaceutical Sciences

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NEW DERIVATIVES OF 2-THIOPHENE CARBOXYLIC ACID: SYNTHESIS, STRUCTURE AND ANTIMICROBIAL STUDIES

CARMELLINA DANIELA BĂDICEANU 1, DIANA CAMELIA NUȚĂ 1*, ALEXANDRU-VASILE MISSIR 1, MĂDĂLINA HRUBARU 2, CRISTINA DELCARU 4, LIA MARA DIȚU 3, MARIANA-CARMEN CHIFIRIUC 3,4, CARMEN LIMBAN 1

1.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, Bucharest, 020956, Romania
2.“C. D. Nenițescu” Organic Chemistry Center, Romanian Academy, 202B Splaiul Independenței, 060023, Bucharest, Romania
3.Department of Microbiology-Immunology, Faculty of Biology, University of Bucharest, 1-4 Aleea Portocalelor, 60101, Bucharest, Romania
4.Research Institute of the University of Bucharest, ICUB, Earth, Environmental and Life Sciences Division University of Bucharest, 90 Panduri Street, 060101, Bucharest, Romania
*corresponding author: diananuta@yahoo.com

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Thiourea and thiophene substructural units have an important significance as bioactive centres in the compounds containing these core units, as are known to display a large spectrum of pharmacological properties. This article is focused on the investigation of the antimicrobial activity of new thiourea and thiophene derivatives. Candidiasis, an important fungal infection, is considered the fourth most common nosocomial blood stream infection. Nowadays, because of increased resistance to antifungal agents, the search for new compounds has gained particular attention. Seven new thiourea derivatives having thiophene ring, obtained from 2-thiophenecarboxilic acid, have been synthesized. The new compounds were characterized for their physical properties (melting point, solubility), and by FT-IR and NMR spectroscopy. The antifungal activity of the obtained compounds was assessed in vitro by qualitative and quantitative (minimum inhibitory concentration) (MIC) assays.