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MURINE STUDIES REGARDING THE TISSUE INTAKE OF DIFFERENT MAGNESIUM COMPOUNDS

CORINA MOISA 1, LAURA GRAȚIELA VICAȘ 1, MARIANA GANEA 1, ERIKA ANDREA LEVEI 2, OANA CADAR 2*, CRISTIAN BERCE 3

1.University of Oradea, Medicine and Pharmacy Faculty, Department of Pharmacy, 29 Nicolae Jiga Street, 410028, Oradea, Romania
2.INCDO-INOE 2000, Research Institute for Analytical Instrumentation, 67 Donath Street, 400293 Cluj-Napoca, Romania
3.“Iuliu Hațieganu” University of Medicine and Pharmacy, Centre for Experimental Medicine, Laboratory Animal Facility, 6 Louis Pasteur Street, 400349, Cluj-Napoca, Romania
*corresponding author: oana.cadar@icia.ro

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The content of magnesium in different mice tissues (heart, liver, spleen, kidney and lung) after administration of different magnesium compounds was studied. Doses of 25, 50, 100, 200 and 300 mg of magnesium -orotate, -sulphate, -oxide, -carbonate, -citrate and -chloride were orally administered to groups of 2 mice for each dose and compound. Tests results showed that the magnesium levels decreased in the following order: orotate > sulphate > chloride > carbonate > citrate > oxide. No side effects were observed in the case of orotate, carbonate and chloride; in the case of oxide and citrate a moderate laxative effect was observed, while in the case of sulphate an intense laxation was noticed. The highest concentrations of magnesium were found in the liver, while the lowest concentrations were found in the lung. It is possible that the chemical structure of magnesium orotate facilitates the bioavailability and higher tisular concentrations of magnesium.