Romanian Society of Pharmaceutical Sciences
 

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MICROBIOLOGICAL EVALUATION AND PRESERVATIVE EFFICIENCY OF NEW MANDELIC ACID DERIVATIVES IN OINTMENTS

CĂTĂLINA DANIELA STAN1, ALINA ŞTEFANACHE2, GABRIELA TĂTĂRÎNGĂ3*, MARIA DRĂGAN1, CRISTINA GABRIELA TUCHILUŞ4

“Grigore T. Popa” University of Medicine and Pharmacy Iaşi, 16 Universităţii Street, 700115, Iaşi, Romania
1 .Department of Drug Industry and Pharmaceutical Biotechnologies, Faculty of Pharmacy
2 .Department of General and Inorganic Chemistry, Faculty of Pharmacy
3 .Department of Organic Chemistry, Faculty of Pharmacy
4 .Department of Microbiology, Faculty of Medicine

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The aim of this study was to investigate the antibacterial and antifungal activity of oxi-acetyl mandelic acid and oxipropionyl mandelic acid and also to evaluate the preservative efficiency of these two new mandelic acid derivatives in ointments. The antimicrobial activity was determined by the agar disk diffusion method and by microdilution broth technique, according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. The results show that these two mandelic acid esters were found to be effective against the tested microorganisms and exert a good antibacterial and antifungal activity at low concentrations. The oxi-acetyl mandelic acid and oxi-propionyl mandelic acid were included in 0.0125 g % and respectively 0.05 g % concentrations in ointments samples, and it was evaluated the efficiency of the preservative action for 28 days, in the presence and in the absence of the test microorganisms - Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 90028. The tested mandelic acid esters proved to have a very good preservative action and could be used to preserve ointments in 0.0125 g % and respectively 0.05 g % concentrations.