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MECHANISM AND THERAPEUTIC ROLE OF JIANPI JIEDU DECOCTION IN PROMOTING HEALING OF RECURRENT ORAL ULCER LESIONS IN RATS VIA NF-ΚB PATHWAY-MEDIATED OXIDATIVE STRESS AND INFLAMMATORY REBALANCE

XU ZHANG, WEN HU, LIANGFU ZHANG *

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This study investigated the effects of Jianpi Jiedu decoction (JJD) on healing recurrent oral ulcers (ROUs) in rats by modulating oxidative stress and inflammation via the NF-κB pathway. Seventy-two male Wistar rats were used; 12 were selected to prepare tissue emulsions for ROU modelling, and 60 were randomized into six groups: normal, model (ROU induction), positive control (dexamethasone) and three JJD dose groups (high, medium, low). Treatments were administered daily by intragastric gavage for 8 weeks. Oral ulcer area, healing status, oxidative stress factors, proinflammatory cytokines, growth factors and NF-κB pathway-related proteins were assessed post-treatment. The PC and JJD groups showed superior ulcer healing compared to the model group. JJD dose-dependently reduced oxidative stress, inflammatory cytokines, IKKα, NF-κB and increased p-IκBα levels. In conclusion, JJD promotes oral ulcer healing by modulating the NF-κB pathway, reducing oxidative stress and inflammatory responses.