Romanian Society of Pharmaceutical Sciences
 

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INFLUENCE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON ANTIFUNGAL RESISTANCE OF CANDIDA STRAINS ISOLATED FROM VULVOVAGINAL INFECTIONS

IONELA SARBU1, DIANA PELINESCU1*, ILEANA STOICA1, IONESCU ROBERTINA1, LUMINITA DASCALU2, IONELA ALEXANDRU3, CHIFIRIUC CARMEN2, ELENA RUSU4, NEDELCU IOANA1, TATIANA VASSU1

1.University of Bucharest, Faculty of Biology, Genetic Department, 1-3 Portocalelor Alley., Bucharest, Romania
2.University of Bucharest, Faculty of Biology, Microbiology Immunology Department, 1-3 Portocalelor Alley., Bucharest, Romania
3.Matei Basarab Medical Center, 45 Matei Basarab Street, Bucharest, Romania
4.”Titu Maiorescu” University, Faculty of Dental Medicine, 67A Gheorghe Petrascu Street, Bucharest, Romania

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In the last few years, it has been noticed an increasing number of infections caused by opportunistic yeasts, due to the development of new therapies and the use of antimicrobial drugs with large spectrum. The main goal of our investigation regards the antifungal susceptibility of pathogenic yeast strains and the effect of non-steroidal anti-inflammatory drugs (NSAIDs) in combination with azole compounds against C. albicans and C. krusei cell viability. Antifungal susceptibility test was performed using Bio-Rad's Fungitest Kit. The most resistant two strains, C. albicans B18 and C. krusei Y8, were selected for further analyses. The influence of anti-inflammatory compounds (aspirin, sodium diclofenac and ibuprofen) on fluconazole and ketoconazole cell susceptibility was assessed. Sodium diclofenac and ibuprofen combined with two selected azole compounds increased the susceptibility of the two Candida strains.