Romanian Society of Pharmaceutical Sciences
 

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INFLUENCE OF MAGNESIUM COMPOUNDS ON SODIUM, POTASSIUM AND CALCIUM LEVELS IN DIFFERENT MICE ORGANS

CORINA MOISA 1, OANA CADAR 2*, REKA BARABAS 3, LAURA GRATIELA VICAS 1, MARIA-ALEXANDRA HOAGHIA 2, ERIKA-ANDREA LEVEI 2, CLAUDIA JURCA 1, CRISTIAN BERCE 4

1.University of Oradea, Medicine and Pharmacy Faculty, Department of Pharmacy, 29 Nicolae Jiga Street, 410028, Oradea, Romania
2.INCDO-INOE 2000, Research Institute for Analytical Instrumentation, 67 Donath Street, 400293, Cluj-Napoca, Romania
3.Babeș-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos Street, 400028, Cluj-Napoca, Romania
4.“Iuliu Hațieganu” University of Medicine and Pharmacy, Centre for Experimental Medicine, Laboratory animal facility, 6 Louis Pasteur Street, 400349, Cluj-Napoca, Romania

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The administration of Mg2+ determines not only the increase of Mg2+, but also induces changes in the tissular levels of Ca2+, K+ and Na+. The effects of dietary Mg2+ on macro-elements (Ca2+, K+, Na+) levels in mice tissues (heart, liver, spleen, kidney and lung) were investigated in a murine study. Doses of 300, 200, 100, 50 and 25 mg of different Mg compounds (orotate, sulphate, oxide, chloride, carbonate, citrate) were administrated by gavage. The results showed that Na+ and K+ levels increase, while Ca2+ levels decrease with the increase of the Mg2+ level. In all organs, macro-elements levels decrease in the following order: K+ > Na+ > Ca2+. The highest intracellular Na+, K+ and Ca2+ levels were obtained in the case of Mg-orotate administration, while no significant changes in the intracellular Na+, K+ and Ca2+ levels were obtained by Mg supplementation as oxide, citrate or carbonate. The principal component analysis confirmed that the increase of intracellular Na+ is accompanied by the increase of intracellular K+ and vice versa. Also, high intracellular Ca2+ levels are expected at low Mg2+ doses.