Romanian Society of Pharmaceutical Sciences
 

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INFLUENCE OF ENVIRONMENTAL CHLOROFORM CONCENTRATIONS ON BIOPHYSICS SKIN PARAMETERS

DANIELA CIORBA1*, ALEXANDRU TATARU3, ADRIAN AVRAM3, ALEXANDRA ALMASI4, MIRELA MOLDOVAN2

1.Environment Science Faculty, Babes-Bolyai University, Cluj-Napoca, Romania
2.Iuliu Hatieganu University, Medicine Faculty, Dermatologic Clinic, Cluj-Napoca, Romania
3.Science Faculty, Aalborg University, Aalborg, Danemark
4.Iuliu Hatieganu University, Faculty of Pharmacy, Cluj-Napoca, Romania

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Our studies were focused on chloroform effect on skin properties. Three concentrations have been tested 100, 200 and 300 μg/L. These levels of concentrations can be found in swimming pools, where this compound results after the water chlorination. An original contact method was used, combined with biophysics measurement of several skin parameters: skin hydration (H), transepidermal water loss (TELW) and sebum secretion (S). Twenty volunteers without clinical signs of dermatological diseases have been monitored, before and 15 minutes after the contact of the product with the skin. The recovery was seen after 50 minutes from the beginning. During the contact, skin hydration increased proportionally with the tested concentrations, while the sebum parameter decreased rapidly. The most important change of TEWL was observed for 100 μg/L, and paradoxically, the return to baseline was higher for 300 μg/L. After 50 minutes, only the sebum parameter didn’t return to the initial values. The exposures of such environmental concentrations determine the skin drying by sebum loss, more pronounced if the initial value of the sebum secretion is low.