Romanian Society of Pharmaceutical Sciences
 

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IN VITRO EFFECTS OF SOME SYNTHESIZED AMINOACETANILIDE N’-SUBSTITUTED ON HUMAN LEUKOCYTES SEPARATED FROM PERIPHERAL BLOOD

ANA CORINA IONIȚĂ 1, MANUELA GHICA 2, ELENA MOROȘAN 1*, FLORICA NICOLESCU 3, MAGDALENA MITITELU 1

1.University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Department of Clinical Laboratory and Food Safety, 6 Traian Vuia Street, 020956, Bucharest, Romania
2.University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Department of Biostatistics, 6 Traian Vuia Street, 020956, Bucharest, Romania
3.University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Department of Toxicology, 6 Traian Vuia Street, 020956, Bucharest, Romania

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Local anaesthetics are frequently used in several medical areas like surgical interventions, stomatology or preparing the patient for imagistic techniques like endoscopies. In most cases, the local anaesthetics are administrated in inflammatory processes and several studies demonstrated that these drugs may influence the response of local immune system cells. The adverse effects reported are correlated with the route of administration and the interaction with cellular components at the site of administration. Some lidocaine analogues with aminoacetanilide N’-substituted structure were previously synthesized, characterized and pharmacologically tested in preclinical studies regarding the local anaesthetic effects and were selected for the present research. The study aims to determine the effects of the synthetized aminoacetanilide N’-substituted on the release of oxygen metabolites by polymorfonuclear cells and on the cellular viability of human leukocytes isolated from the peripheral blood.