IDENTIFYING THE RISK FACTORS FOR LOW BONE MINERAL DENSITY DISORDERS IN HIV-POSITIVE PATIENTS UNDERGOING ANTIRETROVIRAL THERAPY FROM THE ROMANIAN COHORT
ANCA NEGRU 1,2#, CĂTĂLIN TILIȘCAN 1,2*, ANA-MARIA TUDOR 1,2#, CRISTIANA OPREA 1,3, IRINA IANACHE 3, MIHAI LAZĂR 1,2#, DANIELA MUNTEANU 1,2, MARIANA MARDARESCU 2, ADRIAN STREINU-CERCEL 1,2, VICTORIA ARAMĂ 1,2#, ȘTEFAN SORIN ARAMĂ 1,2
1.Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2.Prof. Dr. Matei Balș National Institute for Infectious Diseases, Bucharest, Romania
3.Victor Babeș Clinical Hospital for Infectious and Tropical Diseases, Bucharest, Romania
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The aim of this study was to determine the prevalence and risk factors for osteopenia and osteoporosis among HIV infected patients from the Romanian cohort. We performed a cross-sectional study over a three-year period on HIV positive patients from the Romanian cohort which were in National Institute of Infectious Diseases “Prof. Dr. Matei Balș”, Bucharest, Romania evidences. We calculated patient`s body mass index (BMI), we determined CD4 cell count, HIV viral load and 25-OH-vitamin D plasma levels. All patients had whole body bone mineral density (BMD) measured by Dual X-Ray Absorptiometry (DXA) scan and 29 of them also had hip and lumbar spine DXA scan. We enrolled 46 patients, 25 females. According to the T score at whole body examination 14 and 3 patients were diagnosed with osteopenia and osteoporosis, respectively. Lumbar spine osteopenia and osteoporosis were diagnosed in 7 and 2 patients, respectively. Hip osteopenia and osteoporosis were diagnosed in 4 and 2 patients, respectively. Regarding the Z score, 3 patients had values below the expected range at whole body examination and 2 had low values at both hip and lumbar spine. In patients with detectable HIV viral load low whole-body BMD was negatively correlated with HIV viremia. Patients with low plasma 25-OH-vitamin D levels had lower whole-body Z score means and those with viral hepatitis co-infections had lower lumber spine T and Z score means. High HIV viral load, low vitamin D levels and viral hepatitis co-infections may be indicators for BMD disturbances in patients with HIV infection.
