Romanian Society of Pharmaceutical Sciences
 

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HPLC/MS ANALYSIS OF CAFFEIC AND CHLOROGENIC ACIDS FROM THREE ROMANIAN VERONICA SPECIES AND THEIR ANTIOXIDANT AND ANTIMICROBIAL PROPERTIES

ANDREI MOCAN1, LAURIAN VLASE2, ANDREEA LETIȚIA ARSENE3*, DAN VODNAR4, CRISTINA BISCHIN5, RADU SILAGHI-DUMITRESCU5, GIANINA CRIȘAN1

1.Department of Pharmaceutical Botany, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8, V. Babes Street, Cluj- Napoca, Romania
2.Department of Pharmaceutical Technology and Biopharmaceutics, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8, V. Babes Street, Cluj-Napoca, Romania
3.Department of Biochemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6, Traian Vuia Street, sector 2, Bucharest, Romania
4.Department of Food Science, Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 3-5, Manăştur Street, Cluj-Napoca, Romania
5.Department of Chemistry and Chemical Engineering, “Babeș-Bolyai” University, 11, A. Janos Street, Cluj-Napoca, Romania

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Aerial parts of Veronica species are used in Romanian traditional medicine for the treatment of various conditions like kidney diseases, cough, and catarrh, and are known for their wound-healing properties. In the present study three relevant Veronica species (Plantaginaceae), namely V. officinalis L., V. teucrium L. and V. orchidea Crantz from the Romanian spontaneous flora were investigated considering their content in caffeic and chlorogenic acids, antioxidant and antibacterial properties against anaerobic bacteria. The identification and quantification of the phenolic compounds performed by LC/MS revealed the presence of the two phenolic acids in all samples. The antioxidant potential investigated by several assays showed V. officinalis and V. orchidea as superior sources of natural antioxidants. The antibacterial screening against two anaerobic bacterial strains was assessed by a micro-dilution technique; the results indicating V. teucrium and V. orchidea extracts being more active on Peptostreptococcus anaerobius.