Romanian Society of Pharmaceutical Sciences
 

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GERANYLGERANYLACETONE REDUCES RADIATION-INDUCED DEGENERATION OF SEMINIFEROUS EPITHELIUM IN MICE

BOGDAN HORAŢIU ŞERB1, ALINA ORMENIŞAN2*, VLAD PRELUCA1, MIHAELA CERNUŞCĂ-MIŢARIU1, MIHAI IOAN MIŢARIU1

1.Faculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Street, 550169, Sibiu, Romania
2.Department of Oro-Maxillo-Facial Surgery, Târgu-Mureș University of Medicine and Pharmacy, Târgu-Mureș, Romania

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Geranylgeranylacetone (GGA) has been shown to have cytoprotective effects against a variety of stressors via the induction of the heat shock response. In this study, male mice received GGA by gavage in doses of 250 mg/kg body weight (kg bw) and 1000 mg/kg bw daily for 5 days. The controls received the corresponding volume of vehicle. In the last day of treatment, all mice received a single dose of 4 gray (Gy) total body irradiation. Blood samples were collected before irradiation and at 2 and 8 days post-irradiation. The testes were removed after euthanasia, in the 8th day post-irradiation, for histological analysis. The results showed significant post-irradiation reduction of leukocyte and platelet counts, with no significant difference between treatment groups and controls. The seminiferous tubule proliferation status was significantly higher in mice treated with 1000 mg/kg bw GGA. In conclusion, GGA reduces radiation-induced degeneration of the seminiferous epithelium in mice.