Romanian Society of Pharmaceutical Sciences
 

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FORMULATION AND EVALUATION OF IN VITRO RELEASE KINETICS OF NA3CADTPA DECORPORATION AGENT EMBEDDED IN MICROEMULSION-BASED GEL FORMULATION FOR TOPICAL DELIVERY

VICTOR COJOCARU1, AURELIAN EMIL RANETTI2, LAVINIA GEORGETA HINESCU3, MIHAELA IONESCU3, CRISTIANA COSMESCU3, ANGELA GABRIELA POȘTOARCĂ3, LUDMILA OTILIA CINTEZĂ4*

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia, 020956, Bucharest, Romania
2.“Carol Davila” Military Hospital, 88 Mircea Vulcănescu, 010825, Bucharest, Romania
3.Army Center for Medical Research, 24-28 Gr. Cobălcescu, 010195, Bucharest, Romania
4.University of Bucharest, Faculty of Chemistry, 4-12 Regina Elisabeta, 030018, Bucharest, Romania

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The purpose of this study was to evaluate the in vitro release kinetics of Na3CaDTPA, a well-known and widely-used decorporation agent, from a topical microemulsion-gel formulation in comparison with a conventional gel. For the preparation of hydrogels, Carbopol 934 polymer was used. Release studies were conducted using both hydrophobic (polycarbonate) and hydrophilic (mixed cellulose esters) membranes. The release kinetics were evaluated using Franz diffusion cells. The receptor compartment was filled with phosphate buffer pH 7.4 and magnetically stirred at 600 rpm during the experiments. The temperature of the entire setup was maintained at 32 ± 0.5°C. The microemulsion-gel showed a higher diffusion coefficient and a smaller lag time compared to the conventional gel. The release profiles were evaluated using different kinetic models: zero-order, first-order, Higuchi and Korsmeyer-Peppas. Mathematical modelling of the drug release data suggested a quasi-Fickian diffusion mechanism for both conventional and microemulsion-based hydrogels.