Romanian Society of Pharmaceutical Sciences
 

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FLUOXETINE INFLUENCE ON BODY WEIGHT, SERUM ADIPONECTIN LEVEL AND ADIPOSE TISSUE TRIGLYCERIDES LEVELS IN RATS

MELINDA KOLCSÁR1, ZSOLT GÁLL1,2*, ISTVÁN LÓRÁNT BÍRÓ1, LÁSZLÓ ISTVÁN BÁBA1, ANNAMARIA IMRE2, MARIA T. DOGARU1, ORSOLYA MÁRTHA3

1.Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu Mureș, Gh. Marinescu Street, No. 38, Târgu Mureș, Romania
2.Doctoral School, University of Medicine and Pharmacy of Tîrgu Mureș, Gh. Marinescu Street, No. 38, Târgu Mureș, Romania
3.Department of Urology, Faculty of Medicine, University of Medicine and Pharmacy of Tîrgu Mureș, Gh. Marinescu street, No.38, Târgu Mureș, Romania

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The effects of fluoxetine on metabolic parameters are poorly understood. Adiponectin is an adipocyte hormone inversely correlated with body fat percentage in adults. The aim of this study was to investigate the hormonal changes and metabolic parameters of the perirenal adipose tissue of rats. Two doses (6 mg/kgbw and 12 mg/kgbw) of oral fluoxetine were administered, and dose- and sex-dependent body weight changes were observed. In male rats a weight gain was observed in the control group, instead in the treated groups the high doses of fluoxetine partially blocked this effect. In treated female rats no body weight changes were observed compared to the control group. The perirenal adipose tissue triglyceride content reduction with a simultaneous elevation of plasma adiponectin level suggests that fluoxetine had important peripheral effects.