Romanian Society of Pharmaceutical Sciences
 

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Fe3O4/SALICYLIC ACID MAGNETIC NANOPARTICLES DELIVERY ROUTE. A SIMPLE METHOD FOR TISSUE TARGETING

ADELA-LUIZA CHIRILĂ 1, ION MÎNDRILĂ 1*, DAN EDUARD MIHAIESCU 2, BOGDAN MÎNDRILĂ 1, CRISTINA PREDOI 1, OVIDIU MARCEL MĂRGINEAN 1, IONICA PIRICI 1, GABRIELA RĂU 3, ALICE SANDRA BUTEICĂ 3

1.Morphological Sciences Department, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Craiova, Romania
2.“Costin Nenițescu” Department of Organic Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Bucharest, Romania
3.Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania

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Administration routes can greatly influence the pharmacokinetics, biodistribution and toxicity profile of the iron oxide nanoparticles. The purpose of this study was to investigate on a rat model the effect of three main administration routes of an aqueous dispersion of Fe3O4/salicylic acid magnetic nanoparticles (SaMNPs) on the pattern of their intravisceral storage. In order to identify the SaMNPs aggregates in the viscera we used Perl’s Prussian blue stain. Specific tissue or cell targeting for SaMNPs deposits can be obtained by either of the three delivery systems employed in our study. The aerosol-mediated delivery is recommended for pulmonary and cardiac tissues targeting, the intravenous route is preferable for hepatic and renal tissues targeting and the intragastric administration is the recommended route for SaMNPs delivery to the hepatic, renal and cardiac tissues.