Romanian Society of Pharmaceutical Sciences

« Back to Farmacia Journal 2/2016

EXPERIMENTAL RESEARCHES REGARDING THE MONTELUKAST INFLUENCE IN GENTAMICIN INDUCED ACUTE NEPHROTOXICITY

OANA TESLARIU1, LUMINIȚA AGOROAEI2, LILIANA MITITELU-TARȚĂU3, CARMEN ZAMFIR4, ELENA TESLARIU5, MIHAI NECHIFOR3*

“Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
1.Department of Pediatrics, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
2.Department of Toxicology, Faculty of Pharmacy, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
3.Department of Pharmacology, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
4.Department of Histology, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
5.Department of Biochemistry, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

Download Full Article PDF

We investigated the effects of montelukast (Mk) in acute kidney injury (AKI) experimentally induced by gentamicin (Ge). We used Wistar rats, distributed in 4 groups: group I (control): distilled water 0.5 mL/100 gbw p.o. 10 days; group II (Ge): Ge 80 mg/kgbw i.p. 7 days; group III (Ge + Mk): Ge 80 mg/kgbw i.p. 7 days and Mk 10 mg/kgbw p.o. 10 days; group IV (Mk): Mk 10 mg/kgbw p.o. 10 days. The following parameters: serum concentration of urea, creatinine, superoxide dismutase (SOD), glutathione peroxidase (GPx), total antioxidant status (TAS) and urinary proteins levels were determined before the experiment (I0) and after 3, 7 and 10 days, and the kidneys were anatomo-pathologically evaluated. After 7 days, urea and creatinine levels significantly (p < 0.001) increased, while SOD, GPx and TAS significantly (p < 0.001) decreased in Ge group, compared with I0 and with Ge + Mk, Mk, respectively with the control groups. Mk reduced the severity of renal lesions induced by Ge. The dose of 10 mg/kgbw of Mk revealed a protective renal effect on the experimental AKI induced by Ge.