Romanian Society of Pharmaceutical Sciences
 

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EXPERIMENTAL RESEARCHES REGARDING THE MONTELUKAST INFLUENCE IN GENTAMICIN INDUCED ACUTE NEPHROTOXICITY

OANA TESLARIU1, LUMINIȚA AGOROAEI2, LILIANA MITITELU-TARȚĂU3, CARMEN ZAMFIR4, ELENA TESLARIU5, MIHAI NECHIFOR3*

“Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
1 .Department of Pediatrics, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
2 .Department of Toxicology, Faculty of Pharmacy, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
3 .Department of Pharmacology, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
4 .Department of Histology, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
5 .Department of Biochemistry, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

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We investigated the effects of montelukast (Mk) in acute kidney injury (AKI) experimentally induced by gentamicin (Ge). We used Wistar rats, distributed in 4 groups: group I (control): distilled water 0.5 mL/100 gbw p.o. 10 days; group II (Ge): Ge 80 mg/kgbw i.p. 7 days; group III (Ge + Mk): Ge 80 mg/kgbw i.p. 7 days and Mk 10 mg/kgbw p.o. 10 days; group IV (Mk): Mk 10 mg/kgbw p.o. 10 days. The following parameters: serum concentration of urea, creatinine, superoxide dismutase (SOD), glutathione peroxidase (GPx), total antioxidant status (TAS) and urinary proteins levels were determined before the experiment (I0) and after 3, 7 and 10 days, and the kidneys were anatomo-pathologically evaluated. After 7 days, urea and creatinine levels significantly (p < 0.001) increased, while SOD, GPx and TAS significantly (p < 0.001) decreased in Ge group, compared with I0 and with Ge + Mk, Mk, respectively with the control groups. Mk reduced the severity of renal lesions induced by Ge. The dose of 10 mg/kgbw of Mk revealed a protective renal effect on the experimental AKI induced by Ge.