Romanian Society of Pharmaceutical Sciences

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EXPERIMENTAL PHARMACOLOGICAL RESEARCH REGARDING THE ANTI-OBESITY EFFECT AND THE MOTOR BEHAVIOR INDUCED BY SOME NEWLY SYNTHETIZED β3 ADRENERGIC RECEPTORS AGONISTS IN NORMAL MICE

EMIL ŞTEFĂNESCU1, AURELIA NICOLETA CRISTEA1, CORNEL CHIRIŢĂ1*, GABRIELA PUTINA2

1Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila – Traian Vuia str. no. 6 – Bucharest
2Romanian National Institute of Chemical-Pharmaceutical Research and Development – Bucharest

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A series of newly synthesized compounds by the Romanian National Institute of Chemical-Pharmaceutical Research and Development Bucharest were studied. These compounds are structurally similar to a series of β3 adrenergic receptors agonists, some of which being under clinical trials. The research was directed towards investigating the effect of these compounds on the eating behavior of mice and their body mass evolution, taking into account the fact that the scientific literature already mentions some anti-obesity effects of the β3 agonists. Experimental trials were also performed in order to observe if the new compounds influence the activity of the central nervous system. Thus was determined the motor activity. The new substances were conventionally named C1, C2, C3, C6. From all studied compounds, C3 showed one of the highest prevention of the weight gain in mice, without influencing the motor activity.