EVALUATION OF ENDOTOXEMIA, SOLUBLE CD14 AND IL-1Β IN DOGS WITH INTESTINAL DYSBIOSIS THAT WERE TREATED WITH PROBIOTICS: A PROSPECTIVE STUDY
MARIA-CĂTĂLINA MATEI 1, SANDA ANDREI 1, VICTORIA BUZA 1, MIHAI CERNEA 1*, DARIA ANTONIA DUMITRAȘ 1, DANIELA NEAGU 1, HORAȚIU RAFA 1, CRISTIAN PAUL POPOVICI 1, RALUCA POP 2, ADRIAN CĂTINEAN 2, EUGEN ȘTEFĂNUȚ 3, LAURA CRISTINA ȘTEFĂNUȚ 1
1Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Romania
2“Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania 3EST Research, Bucharest, Romania
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The aim of this study was to compare the serum endotoxin levels in correlation with soluble CD14 and IL-1β in dogs with intestinal dysbiosis that were treated with a probiotic product containing Bacillus subtilis, Bacillus licheniformis and Pediococcus acidilactici. Levels of serum endotoxin, soluble CD14 and IL-1β were assessed before meal consumption, and 6 and 12 h after meal consumption, both prior to initiation of probiotic treatment and after completion of 30 days of treatment. Pre-meal serum endotoxin levels decreased by 25.89% and 6 h and 12 h post-meal levels decreased by 35.00% and 44.93%, respectively, when compared to the respective pre-treatment values which correlated with a decrease in serum soluble CD14 levels, while IL-1β remained approximatively constant
