EVALUATION AND MODELING OF PHARMACOKINETICS OF COPPER ION DURING HEMODIALYSIS
MIHAIL SILVIU TUDOSIE1,2, RUCSANDRA DÃNCIULESCU MIULESCU1*, V. NEGULESCU1, MIHAI IONICÃ2, SIMINA DANIELA STEFAN4, GEORGE CORLAN1, R. MACOVEI1,3
1University of Medicine and Pharmacy “Carol Davila” Bucharest
2Army Center for Medical Research, Bucharest
3Clinical Emergency Hospital, Bucharest
4University Politehnica of Bucharest, Faculty of Applied Chemistry and Material Science, Department of Analitycal Chemistry and Environmental Engineering
Download Full Article PDF
The present study investigated the kinetics of copper levels during renal dialysis.
Plasma and dialysis fluid level of copper where evaluated using an Atomic
Spectrophotometric Absorption method. The evaluation included the determination of mean
blood level of a control group and a chronic renal failure patients group. It was found that
plasma levels of copper were significantly lower in patients than in control group. The
concentration of copper in dialysis fluid was ten times lower than the mean concentration in
blood.
Measurement of time course of copper during dialysis allowed an estimation of
transfer and pharmacokinetic model of copper in patients during dialysis. The model was
conceived as a tricompartmental model: tissue compartment, blood and dialysis fluid
compartment.
Following the fact that the transfer across dialysis membrane is slow, blood
appeared to act as a reservoir, the difference between before and after dialysis blood levels
being moderate.
Time course of copper concentration in dialysis fluid was approximately linearly
dependent on the square root of time. A linear dependence of logarithm of concentration on
time could be considered as an alternative model. In fact, it was difficult to make a correct
hierarchy between the two models, since the number of points and time intervals were not
large enough. But both models suggest the behaviour of blood as a reservoir, not too much
affected by the dialysis and consequently the tricompartment model degeneration as a
pseudo-monocompartmental model.
