Romanian Society of Pharmaceutical Sciences

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EPIDEMIOLOGY AND ANTIBIOTIC RESISTANCE PROFILE OF BACTERIAL UROPATHOGENS IN MALE PATIENTS: A 10-YEAR RETROSPECTIVE STUDY

MÁRIÓ GAJDÁCS 1*, MARIANNA ÁBRÓK 2, ANDREA LÁZÁR 2, KATALIN BURIÁN 2,3

1Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvös utca 6, 6720 Szeged, Hungary
2Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Semmelweis utca 6, 6725 Szeged, Hungary 3Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, 6720 Szeged, Hungary

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The purpose of our present study was to establish the incidence of UTIs in adult male patients in the Southern region of Hungary over a long surveillance period (2008 - 2017). The antimicrobial susceptibility testing was performed using the disk diffusion method. Overall, n = 3750 of these outpatient samples (17.73%) and n = 5902 of inpatient samples (30.54%) originated from male patients. Members of the Enterobacteriaceae family were the most commonly isolated (outpatient: 64.4%, inpatient: 55.57%), with E. coli being the most common urinary pathogen in male patients (outpatient: 37.23%, inpatient: 27.40%), followed by Enterococcus spp. (outpatient: 22.72%, inpatient: 23.43%), and P. aeruginosa (outpatient: 7.15%, inpatient: 9.2%). Between 2010 and 2017, n = 501 (62.65 ± 13.51 per year) extended-spectrum β-lactamase (ESBL) - positive isolates were recorded from outpatients and n = 737 (105.28 ± 31.99 per year) from inpatients (p = 0.032). Similarly to other bacterial infections, patients affected by drug-resistant urinary pathogens may encounter a poor clinical outcome and complications.