EFFECTS OF OXIDATIVE STRESS AND PHARMACOLOGYCAL TREATMENT ON GERIATRIC SYNDROMES IN THE HOSPITALIZED ELDERLY PATIENTS
ADINA CARMEN ILIE, IOANA DANA ALEXA*, ANCA IULIANA MOROŞANU, ADRIAN COVIC, VASILE CEPOI
"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania
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Oxidative stress is an important risk factor in ageing process and influences the evolution of most diseases and geriatric syndromes in the elderly. This evolution is also affected by the pharmacokinetics and pharmacodynamics age-induced particularities of the elderly, which lead to an increased risk for negative side effects and drug-induced toxicity than in the adult patient. We performed a cohort, prospective study on 139 patients aged over 65 years. The aim of the study was to determine the effects of oxidative stress and cardiovascular pharmacological treatment on geriatric syndromes in the elderly patients. Oxidative stress was quantified by measuring the advanced glycated end products (AGE) with a skin autofluorescence method. Geriatric syndromes were determined with comprehensive geriatric assessment. Cardiovascular drugs studied were: beta blocker, angiotensin converting enzyme inhibitors (ACE-I) and anticoagulants. The mean age in the study cohort was 75.35 ± 6.46 and the mean level of AGEs was 2.87 (3.27 - 2.56) AU. The levels of AGE were significantly correlated with the presence of heart failure (p = 0.014, r = 0.280) and with the cognitive status (p < 0.05, r = 0.206). ACE-I treatment had a positive correlation with a low depression score (p < 0.05, r = 0.235) and beta blocker treatment correlatedwith a low score on abilities to live independently (p < 0.05, r = 0.233). The anticoagulant therapy was associated with the cognitive impairment (p < 0.05, r = -0.214), patients with anticoagulant treatment had a higher score in the mini mental state examination (MMSE) than patients without anticoagulant treatment (p < 0.05). Oxidative stress and pharmacological treatment had correlations with geriatric syndromes.