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EFFECTS OF ORAL ATORVASTATIN ON INFLAMMATORY MARKERS AND POSTOPERATIVE DELIRIUM IN ELDERLY PATIENTS WITH HIP FRACTURE SURGERY

GUODONG HU, ANHUA LONG, JALONG WANG, XUEFEI WANG *

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The aim of this study was to evaluate the therapeutic effect of dexmedetomidine anaesthesia assisted in elderly patients with osteoporotic hip fracture combined with postoperative oral atorvastatin, alendronate and calcium intake. A total of 60 elderly patients with osteoporotic hip fractures requiring surgical treatment were selected as the research subjects. They were randomly divided into group I (conventional surgery combined with postoperative alendronate), group II (dexmedetomidineassisted surgery combined with postoperative alendronate and calcium intake) and group III (dexmedetomidine-assisted surgery combined with postoperative alendronate, calcium and atorvastatin intake), 20 patients per group. Serum inflammatory cytokine levels, cognitive function, sedation, pain, delirium, fracture healing rate and incidence of adverse reactions were analysed in each group. The results showed that compared with group I, postoperative serum interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumour necrosis factor α (TNF-α) and c-reactive protein (CRP) levels in groups II and III significantly decreased, while IL-10 significantly increased. Compared with group I, the Mini-Cog score and Ramsay score of group II and group III increased, while the visual analogue scale (VAS) score significantly decreased in groups II and III and the effect was superior in group III. The total delirium rates in groups I, II and III were 15.0%, 5.0% and 5.0%, respectively, the fracture healing rates were 90.0%, 90.0% and 100.0%, respectively, while the adverse reaction rates were 55.0%, 40.0% and 35.0%, respectively. Dexmedetomidine anaesthesia combined with postoperative alendronate, calcium and atorvastatin administration can reduce inflammation, delirium and adverse reaction rates and can be considered for clinical application.