Romanian Society of Pharmaceutical Sciences
 

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EFFECT OF PLATICIZERS ON IN VITRO RELEASE AND EX VIVO PERMEATION OF CHLORPHENIRAMINE MALEATE FROM ETHYL CELLULOSE POLYVINYL PYRROLIDONE BASED MATRIX PATCHES

RAJAN RAJABALAYA*1,2, SHEBA RANI NAKKA DAVID1,3, JASMINA KHANAM2, ARUNABHA NANDA2

1Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil 57000, Kuala Lumpur, Malaysia.
2 Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India.
3 School of Bioscience & Engineering, Jadavpur University, Kolkata- 700032, India.

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The present release and permeation studies were carried out for developing transdermal therapeutic systems with chlorpheniramine maleate (CPM). The matrix patches were prepared from ethyl cellulose (EC) with polyvinyl pyrrolidone (PVP) as the copolymer and plasticizers like dibutyl phthalate (DBP), dibutyl sebacate (DBS), triethyl citrate (TEC), acetyl triethyl citrate (ATEC), tributyl citrate (TBC) and acetyl tributyl citrate (ATBC) in different percentages. Thickness, tensile strength, elasticity, drug content, moisture content and water absorption studies of the matrix patches were measured. In vitro release/permeation of CPM was studied in a modified Keshary - Chien diffusion cell. Experimental release/permeation data (percent release and flux, μgm/cm2 .hr) of different formulations of the matrix systems are reported. Also the drug-polymer interaction was investigated by ATR-FTIR studies. This study reports the effect of CPM in EC patch and suitable amount of plasticizer for better controlled release/permeation of CPM; hence this drug could be a potential candidate for transdermal antihistamine applications in film device industry.