Romanian Society of Pharmaceutical Sciences
 

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EFFECT OF OLANZAPINE ON INVASION AND METASTASIS OF LUNG CANCER CELLS AND THE NURSING ROLE OF PATIENTS AFTER CHEMOTHERAPY

LIU YANG 1, XUE YU 2, YING LIN 3, NA YANG 4, DAN LU 1, SHULI ZHANG 1, PING DU 1, XIAOHONG LIU 1, YING SU 1, HE ZHANG 1, GUITING LIU 3*

1.Central Sterile Supply Department, Affiliated HongQi Hospital of MuDanJiang Medical University, Mudanjiang City 157011, Heilongjiang Province, China
2.Department of Pharmacy, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang City 157011, Heilongjiang Province, China
3.Department of Thoracic Surgery, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang City 157011, Heilongjiang Province, China
4.Endocrine Department, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang City 157011, Heilongjiang Province, China

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Chemotherapy-induced nausea and vomiting (CINV), is one of the most common adverse reactions to chemotherapy and the use of preventive medication can influence the success of the therapy. The aim of this study was to assess in vitro and in vivo the effect of olanzapine on the invasion and metastasis of lung cancer cells and the prevention of nausea and vomiting after chemotherapy. The invasion and metastasis of lung squamous carcinoma cells was evaluated in vitro on A549 cells and in vivo on a nude mice non-obese diabetic (NOD)/severe combined immunodeficiency (SCID) lung metastasis model. Also thirty eight lung cancer patients who received chemotherapy were included in the study. The preventive effect of olanzapine on chemotherapy-induced nausea and vomiting was analysed. In vitro experiments showed that olanzapine decreases the cell number and rate of migration and invasion of A549 cells compared to control groups. In vivo olanzapine decreased the metastasis diameter in olanzapine group compared with the control group. The use of olanzapine for preventing chemotherapy-induced nausea and vomiting in lung cancer patients has the benefit of also inhibiting the invasion and metastasis of lung cancer cells.