EFFECT OF INHALED GLUCOCORTICOIDS ON CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MALE PATIENTS WITH OSTEOPOROSIS
QIUQIANG HUANGFU 1*, MIN LI 2, LINA XIAO 1, HONGJIE TAO 1, WEI WANG 1, XINFA FEI 1
1.Respiratory Medicine, Tonglu First People’s Hospital, Tonglu City, 311500, China
2.Respiratory Medicine, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai City, 200025, China
*corresponding author: [email protected]
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The aim of this study was to assess the bone mineral density (BMD) and the clinical changes of male COPD (chronic obstructive pulmonary disease) patients treated with inhaled glucocorticoids for a long time. Eighty cases of COPD patients were selected and divided into osteoporosis group (OP group, 42 cases) and non-osteoporosis group (NOP group, 38 cases). The control group included 40 healthy males (NC group). Pulmonary function (PF) of COPD patients was tested. Body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), bone mineral density (BMD), serum albumin (ALB), serum total protein (STP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine (CREA), serum uric acid (SUA), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) of all subjects were evaluated. Bone mineral density was higher in the NC group, followed by NOP group and OP group (p < 0.05). There was a negative correlation between the accumulated dosages, the application time of inhaled glucocorticoids and BMD of L1 - L4 (lumber vertebra 1 - 4) (p < 0.05). Logistic regression model analysis showed that risk factors for male COPD patients to have osteoporosis include age, sunshine exposure duration < 2h/d, COPD course of the disease and application time of inhaled glucocorticoid while its protective factors are weighted, BMI and reduced accumulated dosages of glucocorticoids.