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EFFECT OF CARBON DIOXIDE LASER COMBINED WITH ANTI-HPV BIOLOGICAL PROTEIN DRESSING ON HPV LOAD IN PATIENTS WITH CONDYLOMA ACUMINATUM

LIQIN LI *, HONG LUO, YONG CHEN, LIFANG LUO

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The aim of this study was to investigate the therapeutic effect of a carbon dioxide (CO2) laser combined with an anti-human papillomavirus (HPV) biological protein dressing on patients with condyloma acuminata (CA). In this study, male CA patients in the hospital were selected as research subjects and enrolled into the control group (30 cases, CO2 laser treatment) and the observation group (30 cases, CO2 laser combined with anti-HPV biological protein dressing treatment). The viral DNA load of the two groups was determined and compared before treatment, after treatment and at 18 months of follow-up. The treatment response rate and relapse rate of the two groups were also compared. After 18 months, both control and observation viral DNA loads were significantly lower (p < 0.05). After treatment and 18 months of follow-up, the viral DNA loads in the observation group were significantly lower than the viral DNA loads in the control group (p < 0.05). The efficacy rate (93.33%) of the observation group was significantly higher than that of the control group (63.33%), the long-term recurrence rate (13.33%) was significantly lower than that of the control group (43.33%), and the adverse reaction rate (23.33%) of the observation group was significantly lower than that of the control group (56.67%) (all p < 0.05). Therefore, a CO2 laser combined with an anti-HPV biologic protein dressing can significantly reduce the HPV load in CA patients, improving the cure rate and reducing the recurrence rate.