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DRY ROSE PETAL EXTRACTS AND COMPRESSED LOZENGES: FORMULATION AND NIR – CHEMOMETRIC QUANTIFICATION OF ACTIVE PRINCIPLES

ALEXANDRU GAVAN ^1*, ANCA MARIA TOIU ², MIRCEA TAMAȘ ³ IOAN TOMUȚĂ ¹

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The purpose of this study was to develop a manufacturing method for dry rose petal extracts and compressed tablet lozenges and a new non-invasive near-infrared (NIR) – chemometric method for the quantification of their total polyphenolic content. Formulations with four different concentrations were obtained through pulverization of Rosa damascena Mill alcoholic extracts on solid isomalt support. The obtained dry extracts were further compressed into tablet lozenges. The total polyphenolic content, expressed in gallic acid, was determined in all samples using the Folin-Ciocalteu reference method and the results were used to calibrate the new developed quantification technique. The best results for the NIR – chemometric technique were obtained by calculating the first derivative of the spectral values and then applying Multiple Scatter Correction (MSC) or Standard Normal Variate (SNV) pre-processing techniques. In this way, the recovery percent of the active principle content was between 99% and 101% for both products, dry extracts and compressed tablet lozenges. In conclusion, high quality dry extracts and compressed lozenges have been developed and the active principles content could be accurately quantified from the pharmaceutical products using NIR spectroscopy and chemometrics.