Romanian Society of Pharmaceutical Sciences
 

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DRUG ALLERGIES DUE TO IgE SENSITIZATION TO α-GAL

FLORIN-DAN POPESCU 1, OANA MARIANA CRISTEA 2*, FLORIANA-ELVIRA IONICĂ 3, MARIANA VIERU 1

1.Department of Allergology,“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2.Department of Microbiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
3.Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania

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Serum specific IgE antibodies for non-primate mammalian carbohydrate galactose-α-1,3-galactose (α-Gal) are associated to α-Gal syndrome: delayed allergy to red meat manifested as anaphylaxis, angioedema or urticaria after ingestion of beef, pig or lamb meat, immediate-onset anaphylaxis at first parenteral exposure to drugs significantly containing α-Gal. IgE-mediated drug allergy in the α-Gal syndrome was reported for some therapeutic monoclonal antibodies, such as cetuximab, snake antivenom, and varicella-zoster vaccine, but there are risks also for colloid plasma volume substitutes, vaccines containing gelatine of porcine/bovine animal origin as an excipient, and drugs with porcine pancreatin or bovine-origin magnesium stearate.