Romanian Society of Pharmaceutical Sciences
 

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DESIGNING NEW MOTHER TINCTURES FOR INCREASED ANTIOXIDANT EFFICIENCY ON INFLAMMATORY INTESTINAL DISEASES

SORINA NICOLETA VOICU 1, ANCA HERMENEAN 2,3, NELI-KINGA OLAH 4,5, LILIANA BADULESCU 6, MIRUNA SILVIA STAN 1*, ANCA DINISCHIOTU 1

1.Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania
2 .The Institute of Life Sciences, “Vasile Goldiș” Western University of Arad, Arad, Romania
3 .Department of Histology, Faculty of Medicine, “Vasile Goldiș” Western, University of Arad, Arad
4 .SC PlantExtrakt SRL, 407059 Rădaia, Cluj-Napoca, Romania
5 .“Vasile Goldiș” Western University of Arad, Faculty of Pharmacy, 86 L. Rebreanu, 310414 Arad, Romania
6 .Department of Bioengineering of Horticulture Systems, University of Agronomic Sciences and Veterinary Medicine, 59 Mărăști Boulevard, 011464 Bucharest, Romania

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Four mother tinctures of Filipendula ulmaria, Fraxinus excelsior, Gaultheria procumbens and Populus tremula were characterized from the point of view of the antioxidant effect, and were tested in vitro on colon cell cultures in order to select the most potent extracts for intestinal inflammatory pathologies. The antioxidant capacity of the selected tinctures was determined by measuring 2,2-diphenyl-1-picryl-hydrazyl (DPPH)-radical-scavenging activity, oxygen radical absorbance capacity (ORAC) and nitric oxide radical scavenging activity. Our results showed that all extracts exhibited antioxidant capacity, but the greatest effect was observed for Filipendula ulmaria. In addition, it was revealed that they were not cytotoxic to intestinal Caco-2 cells, our findings providing valuable information for introducing these tinctures on the Romanian market of homeopathic products.