Romanian Society of Pharmaceutical Sciences

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DESIGN AND EVALUATION OF PROPOLIS-HPC/PVP ELECTROSPUN NANOFIBERS FOR POSSIBLE CUTANEOUS APPLICATIONS

IMREN ESENTÜRK-GÜZEL 1,2# , EVREN ALGIN YAPAR3# , SIMONA CAVALU 4*, İBRAHIM TUĞKAN ŞEKER5 , EBRAR İNAL 6,7, MURAT KARTAL 6,8 , RABIA ÇAKIR2,9, RABIA YILMAZ ÖZTÜRK 2.9, FERIHA GÖKSU 10, SIBEL BÖLEK 10, AYYÜCE TÜRKMEN 1

1Department of Pharmaceutical Technology, Hamidiye Faculty of Pharmacy, University of Health Sciences, Istanbul, Türkiye
2Türkiye Biotechnology Institute, Health Institutes of Türkiye (TUSEB), Istanbul, Türkiye
3Department of Pharmaceutical Technology, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Türkiye
4Department of Preclinical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, Bihor, Romania
5Department of Gastronomy and Culinary Arts, School of Tourism and Hotel Management, Sivas Cumhuriyet University, Sivas, Türkiye 6Department of Pharmacognosy, Faculty of Pharmacy, Bezmialem Vakıf University, Istanbul, Türkiye
7Institute of Health Sciences, Bezmialem Vakıf University, Department of Pharmacognosy and Natural Product Chemistry, Istanbul, Türkiye. 8Phytotheraphy Research Center, Bezmialem Vakıf University, Istanbul, Türkiye
9Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yıldız Technical University, Istanbul, Türkiye 10Department of Food Technology, Experimental Medicine Research and Application Centre, University of Health Sciences, Istanbul, Türkiye

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The aim of the study was to prepare propolis loaded hydroxypropyl cellulose and polyvinyl pyrrolidone (HPC/PVP) nanofibers, suitable for cutaneous applications. LC-HRMS analyses were applied for the identification and quantification of the bio-compounds in the propolis extract. Electrospinning was applied in order to prepare propolis HPC/PVP nanofibers with increasing concentration of propolis 10%, 20% and 30 % (v/v) and subsequently characterized in terms of morphology, wettability, thermal degradation and biological properties. SEM images showed homogenous features of the nanofibers and average diameter between 197.2 - 268.4 nm, high antioxidant activity, very good biocompatibility and no cytotoxicity. Particularly, with the highest propolis concentration, 30-PE/HPC/PVP nanofiber formulation is a promising alternative to conventional treatments for cutaneous applications.