Romanian Society of Pharmaceutical Sciences
 

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CORRELATION BETWEEN TECHNOLOGICAL PROCESS AND ANTIOXIDANT CAPACITY FOR SOPHORAE FLORES FLAVONES SELECTIVE DRY EXTRACTS

FLORENTINA RONCEA1*, VIORICA ISTUDOR2, TICUŢA NEGREANU-PÎRJOL1, MIHAELA BRATU1, MARIA GIURGINCA3, RADU CAZACINCU1

1.“Ovidius” University, Faculty of Pharmacy, Constanta, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest, Romania
3.Politehnica University of Bucharest, Department of Inorganic chemistry, Bucharest, Romania

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Because flavones act as antioxidants and oxidative stress characterizes lead poisoning we determined the antioxidant capacity and TPC (total polyphenol content) for Sophorae flores flavones selective dry extracts that could be used in lead poisoning treatment. The antioxidant capacity was performed by FRAP (Ferric Reducing Antioxidant Power), TEAC (Trolox Equivalent Antioxidant Capacity) and chemiluminescence (CL) methods and TPC (total polyphenol content) assay by Folin – Ciocalteu method. Because the greatest antioxidant capacity correlated with TPC (total polyphenol content) assay was noticed for B flavones selective dry extract, we suggest as a technological process correlated with highest antioxidant capacity the following scheme: vegetal product – solvent ratio (1:10); 40% CH3OH under reflux extraction, 2N HCl hydrolysis, hydrolysis time = 15 h, ethyl acetate aglycon extraction.