COMPARISON OF STONE-FREE RATE WITH CITRATURIA LEVELS IN KIDNEY STONES TREATED WITH DIGITAL FLEXIBLE URETEROSCOPY WITH HOLMIUM LASER LITHOTRIPSY
MIHAI ANDREI ENE 1, PETRIȘOR AURELIAN GEAVLETE 1,2, CĂTĂLIN ANDREI BULAI 1,2, COSMIN VICTOR ENE 1,2, BOGDAN FLORIN GEAVLETE 1,2*
1“Sfântul Ioan” Emergency Clinical Hospital, Urology Department, Bucharest, Romania 2“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, Bucharest, Romania
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The use of citrate treatment (to increase citraturia) may be a solution to help eliminate the remaining fragments (< 5mm) following flexible ureteroscopy and Holmium laser lithotripsy for kidney stones. We performed a prospective, randomized, double-blind trial study on a sample of 149 patients with kidney stones who benefited from digital flexible ureteroscopy with Holmium laser lithotripsy between January 2018 and November 2020. 75 patients then received general treatment with a combination of citrates (975 mg of potassium citrate, 60 mg of magnesium citrate, and 25 mg pyridoxine per sachet) and 74 patients received only general treatment. The sample of patients was divided into two groups (it was not considered whether or not the patient benefited from the combination of citrates): group A consisted of patients who at 90 days obtained stonefree status, while group B consisted of patients who did not obtain this status. The values of citraturia/24 h in group A are statistically significantly increased after 90 days (p < 0.01). Following the comparison between the differences between the citraturia at 90 days and the initial ones in the 2 groups (geometric mean), the difference was higher in group A, the effect being statistically significant (p < 0.05).