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COMPARISON OF LONG TERM ORAL SUPPLEMENTATION WITH TWO DOSAGES OF CHOLECALCIFEROL ON SERUM 25 – HYDROXYVITAMIN D IN PATIENTS WITH POSTMENOPAUSAL OSTEOPOROSIS

DANIEL GRIGORIE ^1,2*, ANDRA CARAGHEORGHEOPOL ¹, DIANA COLEȘ ¹, ALINA ȘUCALIUC ¹

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This study reports on the efficacy of two different daily oral doses of cholecalciferol supplementation (high dose group 1000 IU/day and low dose group 500 IU/day) for one year to 100 patients with postmenopausal osteoporosis (PMO) to achieve serum concentration of 25- hydroxyvitamin D (25OHD) of 20 ng/mL and 30 ng/mL. Two thirds of the whole study group (66%) had values below 20 ng/mL and 90% had < 30ng/mL at baseline. After one year of supplementation, in the high dose group none was deficient, 85.1% had values above 20 ng/mL, half had ≥ 30 ng/mL and the mean serum 25OHD increased from 17.9 to 29.2 ng/mL (p << 0.0001). In the low dose group, 4% of the patients were still deficient, 65.2% had values above 20 ng/mL, 19% above 30 ng/mL and 25OHD increased from 19.3 to 23 ng/mL (p = 0.06). Oral cholecalciferol supplementation for one year with 1000 IU/day is adequate to achieve serum 25OHD concentrations higher than 20 ng/mL for most of the patients. If the target concentration was 30 ng/mL, the treatment is successful only for half of the patients. No vitamin D deficiency was recorded for patients under this dosage after one year.