Romanian Society of Pharmaceutical Sciences
 

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COMPARATIVE ASSESSMENT OF THE BENEFITS OF POTASSIUM AND MAGNESIUM TRIBASIC CITRATE VERSUS TAMSULOSIN IN NEPHROLITHIASIC PATIENTS

CĂTĂLIN PRICOP 1,2#, DRAGOŞ PUIA 1,2#*, DRAGOMIR ŞERBAN 1#, ILEANA PERIDE 3,4#, ANDREI NICULAE 3,4#, VIOREL JINGA 3,5#

1.“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, 16 Universității Street, 700115, Iași, Romania
2 .“C. I. Parhon” Hospital, Department of Urology, 50 Carol I Boulevard, 700503, Iași, Romania
3 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, Clinical Department No. 3, 37 Dionisie Lupu Street, 030167, Bucharest, Romania
4 .“Sfântul Ioan” Emergency Clinical Hospital, Department of Nephrology and Dialysis, 13 Vitan-Bârzești Road, 042122, Bucharest, Romania
5 .“Prof. Dr. Theodor Burghele” Clinical Hospital, Department of Urology, 20 Panduri Road, 050653, Bucharest, Romania
*corresponding author: drdragos83@yahoo.com
#All authors have equal contribution

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Nephrolithiasis is a major health issue. Present guidelines recommend conservative treatment for calculi less than 5 mm. Over the years, various therapeutic regimens to facilitate spontaneous passage of stones have been used without reaching a consensus in this respect. We aimed to compare the efficacy of potassium and magnesium tribasic citrate which has metaphylactic indications with that of a selective alpha-blocker as medical expulsion therapy. The preliminary results of this ongoing study showed that in patients with pelvic ureteric lithiasis, the alpha-blocker-based expulsion treatment was significantly more effective than that based on potassium and magnesium tribasic citrate. As for asymptomatic lumbar ureteric lithiasis below 7 mm in diameter, the alpha-blocker and potassium and magnesium tribasic citrate treatment showed similar results.