Romanian Society of Pharmaceutical Sciences

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COMPARATIVE ASSESSMENT OF THE BENEFITS OF POTASSIUM AND MAGNESIUM TRIBASIC CITRATE VERSUS TAMSULOSIN IN NEPHROLITHIASIC PATIENTS

CĂTĂLIN PRICOP 1,2#, DRAGOŞ PUIA 1,2#*, DRAGOMIR ŞERBAN 1#, ILEANA PERIDE 3,4#, ANDREI NICULAE 3,4#, VIOREL JINGA 3,5#

1.“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, 16 Universității Street, 700115, Iași, Romania
2.“C. I. Parhon” Hospital, Department of Urology, 50 Carol I Boulevard, 700503, Iași, Romania
3.“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, Clinical Department No. 3, 37 Dionisie Lupu Street, 030167, Bucharest, Romania
4.“Sfântul Ioan” Emergency Clinical Hospital, Department of Nephrology and Dialysis, 13 Vitan-Bârzești Road, 042122, Bucharest, Romania
5.“Prof. Dr. Theodor Burghele” Clinical Hospital, Department of Urology, 20 Panduri Road, 050653, Bucharest, Romania
*corresponding author: drdragos83@yahoo.com
#All authors have equal contribution

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Nephrolithiasis is a major health issue. Present guidelines recommend conservative treatment for calculi less than 5 mm. Over the years, various therapeutic regimens to facilitate spontaneous passage of stones have been used without reaching a consensus in this respect. We aimed to compare the efficacy of potassium and magnesium tribasic citrate which has metaphylactic indications with that of a selective alpha-blocker as medical expulsion therapy. The preliminary results of this ongoing study showed that in patients with pelvic ureteric lithiasis, the alpha-blocker-based expulsion treatment was significantly more effective than that based on potassium and magnesium tribasic citrate. As for asymptomatic lumbar ureteric lithiasis below 7 mm in diameter, the alpha-blocker and potassium and magnesium tribasic citrate treatment showed similar results.