Romanian Society of Pharmaceutical Sciences

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COMPARATIVE ANALYSIS OF THE RELEASE PERFORMANCE OF INDOMETHACIN FROM TRANSDERMAL THERAPEUTIC SYSTEMS

PAULA ANTONOAEA 1, MAGDALENA BÎRSAN 2*, NICOLETA TODORAN 1, EMŐKE RÉDAI 1, ROBERT ALEXANDRU VLAD 1, DANIELA-LUCIA MUNTEAN 3, AURA RUSU 4, ADRIANA CIURBA 1

1.“George Emil Paladeˮ University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, 38 Gheorghe Marinescu Street, 540139, Târgu Mureș, Romania
2.“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology, 16 Universitatii Street, 700115, Iași, Romania
3.“George Emil Paladeˮ University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Faculty of Pharmacy, Department of Analytical Chemistry and Drug Analysis, 38 Gheorghe Marinescu Street, 540139, Târgu Mureș, Romania
4.“George Emil Paladeˮ University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 38 Gheorghe Marinescu Street, 540139, Târgu Mureș, Romania

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By their advantages, transdermal therapeutic systems (TTSs) represent an alternative to the conventional pharmaceutical forms. In this study, 3 formulations of TTSs with indomethacin (IND) were developed, which were subjected to analysis by model-independent (by calculation of the f1 and f2 factors; linearization by simple regression), respectively model-dependent methods (modelling with Higuchi function). Release evaluation of the IND was performed using the Franz diffusion cell method through a synthetic or biological membrane, at pH 5.5 and pH 7.4. The obtained results showed that although differences were observed between the analysed release profiles, at an evaluation of the f2 factors there were observed similarities in the shapes of the release curves. By simple linear regression it was determined the diffusion flux through the membranes, which varied depending on the pH and on the type of membrane: 0.749 - 80.270 g/cm2h. The R² < 1 values denote the influence of the ingredients in the IND release. Under certain experimental conditions, the IND3 formulation maintains the steady state for 28 hours at pH 5.5, respectively 12 hours at pH 7.4.