Romanian Society of Pharmaceutical Sciences
 

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COLLAGEN-SERICIN-NANO-HYDROXYAPATITE COMPOSITES FOR BONE TISSUE ENGINEERING

MADALINA GEORGIANA ALBU1, ADRIANA LUNGU2, EUGENIU VASILE2, HORIA IOVU2*

1.INCDTP-Division Leather and Footwear Research Institute, Bucharest, Romania
2 .Advanced Polymer Materials Group, Department of Bioresources and Polymer Science, University Politehnica of Bucharest, Bucharest, Romania

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The aim of this study was to synthetize porous three-dimensional composites, similar with natural bone structure, for using it in tissue engineering. The new composites prepared by freeze-drying of composite gels consist of a mineral phase - nano-hydroxyapatite and an organic phase - type I fibrillar collagen and silk sericin, the latter acting as a glue-like protein that serves as an adhesive, for binding the collagen fibrils and the mineral phase. The physical-chemical properties were assessed using infrared spectroscopy (FTIR) and thermogravimetry (TGA/DTG); the morphological properties were evaluated by scanning electron microscopy (SEM). The evaluation of the physical-chemical and morphological properties demonstrated that the new composites are promising biomaterials for bone tissue engineering.