Romanian Society of Pharmaceutical Sciences
 

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CLINICAL IMPLICATIONS OF THE INDOLERGIC SYSTEM AND OXIDATIVE STRESS IN PHYSIOLOGICAL GESTATIONAL HOMEOSTASIS

ALINA CRENGUŢA NICOLAE1#, CRISTINA MANUELA DRĂGOI1#, IULIANA CEAUȘU2*#, CRISTIAN POALELUNGI2#, DOMINIC ILIESCU3#, ANDREEA LETIŢIA ARSENE1#

1.Department of Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy ”Carol Davila”, 6, Traian Vuia str, sector 2, Bucharest, Romania
2.Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, Department of Obstetrics and Gynecology, Dr. I. Cantacuzino Hospital, 5-7 Ion Movila, Bucharest, Romania
3.Faculty of Medicine, University of Medicine and Pharmacy Craiova, Romania

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The physiological processes of reproduction and a normal intrauterine development ensure the proper functioning of the future adult human body. Physiological pregnancy is characterized by complex changes of the maternal body, which are based on specific biochemical mechanisms. In the present study, there were investigated the normal serum variations of two major neurohormones: melatonin and serotonin and also, the maternal oxidative status in physiological pregnancy, along with the evolution of the gestational age. The main objective of this research was to establish a scientific basis, statistically substantiated, for the future use of these parameters as predictive biochemical markers for some diseases that may compromise the normal development of physiological pregnancy. The experimental results were mathematically processed and we established for the first time in literature, predictive mathematical equations for the normal variation of the investigated biochemical markers, during physiological pregnancy.