« Back to Farmacia Journal 3/2022

CHEMICAL COMPOSITION AND THERAPEUTIC ACTIVITY OF LEBANESE ROSE GERANIUM (PELARGONIUM HYBRID) EXTRACTS

LINA FAYOUMI 1, MAHMOUD KHALIL 2, DOAA GHAREEB 3,4, MOHAMMAD H. EL-DAKDOUKI 1

1Department of Chemistry, Faculty of Science, Beirut Arab University, P.O. Box 11-5020, Riad El Solh 11072809, Beirut, Lebanon
2Department of Biological Sciences, Faculty of Science, Beirut Arab University, P.O. Box 11-5020, Riad El Solh 11072809, Beirut, Lebanon
3Center of Excellence for Drug Preclinical studies (CE-DPS), Pharmaceutical and Fermentation Industry Development
Centre, City of Scientific Research & Technological Applications, New Borg El Arab, Alexandria, Egypt
4Bio-screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt

Download Full Article PDF

The phytochemical constituents were identified, and the antioxidant, antiinflammatory, antiacetylcholinesterase (AChE), cytotoxic, and anti-haemolytic properties were assessed for the leaves and stem extracts of Lebanese rose geranium extracted by four solvents with different polarity (ethanol, water, ethyl acetate and chloroform). The highest amounts of total phenolics (237 GAE mg/g), total flavonoids (356 RE mg/g) and condensed tannins content (441 LE mg/g) were detected in the ethanolic leaves extracts. The antioxidant activity was estimated by four methods, namely DPPH radical scavenging, hydrogen peroxide scavenging, reducing power and β-carotene bleaching assays and the ethanolic leaves extract exhibited the superior antioxidant potential. On the other hand, the chloroform extracts revealed good anti-inflammatory activity. The ethanol and ethyl acetate leaves and stem extracts demonstrated the highest anti-AChE activity with 80% inhibition achieved at 5 mg/mL. The cytotoxic activity of the extracts was evaluated against HCT 116 colon cancer cells, with the chloroform leaves extract being the most potent with an IC50 of 0.4 mg/mL. The toxicity of the extracts was assessed by testing its ability to induce haemolysis of red blood cells, and the water leaves extract was the least toxic.