Romanian Society of Pharmaceutical Sciences
 

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CELLULAR IMPEDANCE MEASUREMENT – NOVEL METHOD FOR IN VITRO INVESTIGATION OF DRUG EFFICACY

MIRCEA TAMPA1, CLARA MATEI1, CONSTANTIN CARUNTU2, TEODOR POTECA3*, DANA MIHAILA3, CATALIN PAUNESCU4, GABRIEL PITIGOI4, SIMONA-ROXANA GEORGESCU1, CAROLINA CONSTANTIN5, MONICA NEAGU5

1.Dermatology Department, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, Bucharest, 050474, Romania
2.Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, Bucharest, 050474, Romania
3.Colentina Hospital, General Surgery Department, 19-21 Stefan Cel Mare, Bucharest, Romania
4.Medical Recovery Department, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, Bucharest, 050474, Romania
5."Victor Babes" National Institute of Pathology, Immunobiology Laboratory, 99-101 Splaiul Independentei, Bucharest, 050096, Romania

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There are a few literature data focusing on impedance measurement of melanocytes’ cellular behaviour. We present herein the impedance measurement as a potential assay for studying the sensitivity of melanocytes, isolated from freshly excised tumours, to standard drugs. The methodology for investigating primary cells sensitivity to cytostatics like dacarbazine is presented. The cellular impedance method is a reliable and rapid method for monitoring dynamic cell behaviour following drug exposure and a future important step toward personalized therapy.