Romanian Society of Pharmaceutical Sciences

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CD64 EXPRESSION IN PATIENTS WITH CHRONIC PROSTATITIS AND ITS IMPLICATION IN DIAGNOSIS

JINGHE CAO 1, BAOGANG SUN 1, YINGYING FAN 1*, ZHUANG LIU 1, NING ZHANG 1

1.Reproductive Center, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, China
*corresponding author: [email protected]

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The aim of this study was to investigate the expression of neutrophil granulocyte cluster of differentiation 64 (CD64) in patients with chronic prostatitis and the significance for diagnosis and treatment of chronic prostatitis. Seventy-two patients with chronic prostatitis were selected and included in the experimental group. Moreover, thirty-five healthy individuals represented the control group. Pathogen detection and the level of CD64 were determined in the prostatic fluids of all individuals included in the study. Fifty-four pathogen stains were detected in the specimens of prostatic fluid of patients in the experimental group and none in the control group. Patients infected with Staphylococcus simulans had the highest expression level of CD64 (3912.237 ± 767.416/cell), followed by Staphylococcus auricularis (2764.371 ± 141.261/cell), Staphylococcus warneri (1916.356 ± 127.284/cell), Enterococcus faecalis (1893.636 ± 314.458/cell) and Staphylococcus haemolyticus (1874.328 ± 125.212/cell) the difference being significant compared to the control group (p < 0.01). There was no significant difference between the expression levels of CD64 in control the group and in patients from the experimental group infected with Chlamydia trachomatis, Ureaplasma urealyticum, Staphylococcus epidermidis, Staphylococcus xylosus, Staphylococcus capitis urealyticum and Staphylococcus hominis. CD64 can be a potent marker for the diagnosis of bacteria chronic prostatitis.